Effect of Anti-Piroplasm Drug on Various Physiological Indices in Healthy Mongrel Dogs

†T. Bashir, †I. Rabbani, *M. A. Khan, †M. Q. Zaman, †M. S. Yousaf, †M. I. Khan and ‡F. Sharif

†Department of Physiology, *Department of Clinical Medicine and Surgery, ‡Department of Parasitology, University of Veterinary and Animal Sciences, Lahore, Pakistan

ABSTRACT

In this study, we aimed to evaluate the changes in hematology, hepatic and renal profile of healthy Mongrel dogs injected with therapeutic doses of Imidocarb dipropionate (IMDP) to determine the changes in physiological indices. Six adult, male and healthy Mongrel dogs, aged above one year, weighing 15-20 kg were injected with two intramuscular doses of Imizol@ 6mg/kg body weight at 48 hours dosage interval. The hematology, renal and hepatic profile was determined on day 1 (pre-treatment) and day 2, 3, 7 (post-treatments). The activity of serum Alanine Aminotransferase (ALT) increased significantly on day 3 compared to the pre-treatment (day-1). The serum creatinine concentration was significantly elevated on day 2 (p<0.05) than its pre-treatment values. However, the serum Aspartate Aminotransferase (AST), Alkaline Phosphatase (AP), complete blood count (CBC), Bilirubin concentration and Blood urea nitrogen (BUN) did not differ significantly between pre-treatment and post-treatment periods. Based on the results obtained, it was concluded that IMDP may induce minor damage to hepatic and renal function, from which dogs recovered during the studied time period.
Key words: Antipiroplasm, Mongrel dogs, Imizol, Hematology, Babesiosis